Irritable Bowel Syndrome and Lactibiane Tolerance

Effect of Lactibiane Tolerance on Symptoms Severity of Irritable Bowel Syndrome

The purpose of this study is to evaluate the effects of a probiotic combination (Lactibiane Tolerance) on the severity of symptoms in patients with irritable bowel syndrome (IBS).

The primary purpose of this study is to evaluate the effects of a probiotic combination (Lactibiane Tolerance) on the severity of symptoms in patients with irritable bowel syndrome (IBS).

The secondary purposes are to evaluate the effects of the intervention on:

• quality of life
• severity of fatigue, anxiety and depression
• levels of inflammatory markers in blood and tools

Inclusion Criteria:

• Irritable bowel syndrome according to the Rome II criteria
• 150< Francis Score < 300
• HAD score inferior or egal to 25

Exclusion Criteria:

• History of hypersensitivity to one of the composant of the product
• Use of probiotics or antibiotics last four weeks
• use of prohibited drugs
• bowel preparation for morphological examination last month
• pregnancy or lactation
• immundepressed or co-existing other serious illness or evolutive