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| Name | Class |
|---|---|
| University of Surrey | OTHER |
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The aim of this investigation was to examine the effects of tart Montmorency cherry juice on urinary 6-sulfatoxymelatonin and sleep quality using a double-blind, placebo-controlled, cross-over design.
The aim of the study is to examine the efficacy of tart cherry juice on sleep quality, quantity, and timing. Naturally circulating melatonin is instrumental in regulating sleep/wake schedules. Tart Montmorency cherries (Prunus Cerasus) contain high levels of melatonin and may be a useful intervention to supplement for realignment of circadian phase and by increasing the robustness of circadian amplitude. In normal healthy adults, with experimentally induced phase advanced circadian misalignment, the administration of a 3mg supplement of melatonin significantly increased sleep architecture characteristics. In this study we want to examine the efficacy of tart cherry juice in increasing urinary levels of melatonin and the subsequent impact this will have on sleep parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Baseline placebo | No Intervention | measures taken before administration of placebo | |
| Placebo | Placebo Comparator | Placebo intervention given after 'baseline placebo' arm |
|
| baseline cherry juice | No Intervention | measures taken before the cherry juice intervention | |
| cherry juice | Experimental | trial where cherry juice is taken following the 'baseline cherry juice' arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cherry juice | Dietary Supplement | 30 mLs preceding morning meal and 30 mLs preceding evening meal each day for 7 days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| urinary 6-sulphatoxymelatonin | urinary 6-sulphatoxymelatonin is the primary metabolite of melatonin and provides a sarrogate marker of melatonin metabolism. By measuring over a 48 h period it is possible to examine the circadian rhythm of melatonin. | continually for 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Sleep quality | Acti watches quantitively measure sleep and activity of participants, whereas slep recall provides a retrospective and subjective m,easure of sleep quality. | continually throughout the duration of the study |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Glyn Howatson, PhD | Northumbria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumbria University | Newcastle upon Tyne | Tyne and Wear | NE1 8ST | United Kingdom |
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| Fruit juice cordial | Dietary Supplement | fruit flavoured juice concentrate |
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