The primary objective of this study is to determine if broccoli sprouts (BS) improves airway inflammatory, oxidative stress (OS), and symptoms among asthmatic adults with aeroallergen sensitization.

The study is a double-blind, placebo-controlled, randomized trial to compare BS to placebo in 40 adults with asthma. 40 adults (age 18-50) who meet these eligibility criteria will be randomized to receive either: (a) BS or (b) placebo (alfalfa sprouts). Subjects will eat a sprouts sandwich daily for three days, and then undergo repeat measurement of outcomes.

Inclusion Criteria:

• doctor diagnosis of asthma
• aeroallergen sensitization
• Non-smoker
• Negative pregnancy test
• Not breastfeeding
• Normal TSH
• For women, abstinent or using reliable birth control
• Age 18-50 years
• No other major pulmonary disease such as cystic fibrosis or COPD
• Willingness to participate in study and sign consent form

Exclusion Criteria:

• Severe or unstable asthma defined as requiring hospitalization in the previous 6 months or intubation in the previous 2 years, or on high-dose inhaled corticosteroids or chronic oral corticosteroids
• Uncontrolled asthma defined as short-acting beta agonist use 3 or more days a week in the previous 4 weeks
• Other significant medical issues such as heart disease or poorly controlled hypertension, type 1 diabetes, poorly controlled type 2 diabetes, or hypothyroidism
• Pregnancy or nursing/breastfeeding mothers
• On beta-blocker therapy
• On reserpine, clonidine, imipramine, or related tricyclic drugs
• Taking anti-oxidant supplements
• Planned dietary changes during the study period
• Unable to stop antihistamines prior to skin testing
• Food allergy to Broccoli Sprouts or Alfalfa Sprouts
• Omalizumab use within the last 12 months
• Nasal polyps