The purpose of this trial is to test the effectiveness of the use of a new therapeutic strategy in treating patients with degenerative disc disease lumbar intervertebral fusion with instrumented posterolateral autologous mesenchymal stem cells and arranged in a calcium phosphate ceramic (Conduit TM).

Inclusion Criteria:

Clinical

• Box symptomatic (back pain and / or root) of lumbar degenerative disc disease monosegmental.
• Discopathy refractory to conservative treatment (drugs, physical therapy.)
• Evolution greater than or equal to 6 months. Radiological
• Discopathy radiation. Disc space narrowing, osteophytes, abnormal mobility, etc
• NMR: grades IV and V of Pfirman.

Exclusion Criteria:

• Rejection of surgical treatment.
• Systemic inflammatory disease (spondylitis, rheumatoid arthritis etc), tumor or infection.
• Immunosuppressive treatment.
• Congenital or acquired anatomical abnormality that prevents the surgical procedure.
• Neuropsychiatric pathology, drug addiction, psychosis, severe personality disorder.
• High surgical risk (ASA> IV), or contraindication to anesthesia.