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The aim of this study is to compare two misoprostol regimen in pregnancy termination.
Studies on determining the optimal dosage for misoprostol in pregnancy termination are continuing and still there is no evidence for ideal misoprostol regimen for pregnancy termination. The aim of this study is to compare two misoprostol regimen in pregnancy termination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 400 microgram misoprostol | Experimental | 400 micrograms misoprostol each 6 hours for 8 dose |
|
| 800 micrograms misoprostol | Active Comparator | 800 micrograms misoprostol each 12 hours for 4 dose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Misoprostol 400 micrograms | Drug | Misoprostol 400 micrograms each 6 hours for 8 dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| Abortion | After 48 hours after treatment each patient is assessed for abortion. Patients are devided into three groups including complete, partial or no abortion. | 48 hours after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of abortion | Duration of abortion Form the begining of treatment to complete abortion | Form the begining of treatment to complete abortion |
| Adverse Effects | including nausea, vomiting, fever and chill, diarhea, abdominal cramp, skin rash |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hormozgan University of Medical Sciences | Bandar Abbas | Hormozgan | 097145-3388 | Iran |
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| ID | Term |
|---|---|
| D016595 | Misoprostol |
| ID | Term |
|---|---|
| D011459 | Prostaglandins E, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
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| Misoprostol 800 micrograms | Drug | Misoprostol 800 micrograms each 12 hours for 4 doses |
|
|
| 48 hours after treatment |
| Need for surgery | Dilatation & cartage | 48 hours after treatment |
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |