Misoprostol for Second Trimester Termination of Pregnancy

Mifepristone (RU 486) and Misoprostol for Second Trimester Termination of Pregnancy. A Comparison of Two Different Dose Regimens.

To compare the efficacy of two different dose regimens of misoprostol administered vaginally in combination with mifepristone in second trimester termination of (non)viable pregnancy.

The study was designed as a prospective double blinded randomised controlled trial, comparing 200µg to 400 µg misoprostol given vaginally at four hour intervals, starting 36-48 hours after the oral administration of mifepristone 200 mg at a gestational age between 14 to 24 weeks.

Inclusion Criteria:

• Women with a gestational age between 14 to 24 weeks, confirmed by ultrasound, requesting termination of pregnancy

Exclusion Criteria:

• No informed consent
• Mifepristone allergy
• Chronic adrenal gland failure
• Kidney failure
• Liver failure
• Chronic use of corticosteroids
• COPD not responsive to treatment
• Cardiovascular disease
• Glaucoma