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| Name | Class |
|---|---|
| Ministry of Defence, United Kingdom | OTHER_GOV |
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This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.
Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fasting | Experimental | Overnight fast |
|
| Feeding | No Intervention | Normal breakfast |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Overnight fast | Other | Overnight fast from 21:00 h |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in C-terminal telopeptide region of collagen type 1 (B-CTX) concentration from baseline | B-CTX is a specific marker of bone resorption. It's circulating concentration is altered by both exercise and feeding | At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Change in parathyroid hormone (PTH) concentration from baseline | PTH is reported to induce both bone resorption and bone formation. It's circulating concentration is altered by both exercise and feeding. | At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jonathan PR Scott, Ph.D | QinetiQ Ltd | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| QinetiQ Ltd | Farnborough | Hampshire | GU14 0LX | United Kingdom |
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| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001862 | Bone Resorption |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| C407088 | Angptl4 protein, mouse |
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