The goal of this research study is to learn if a wellness program can help improve diet and physical activity levels and encourage smoking cessation in Latino individuals who are overweight.

Day 1 Study Visit:

If you are found eligible to take part in this study, the following tests and procedures will be performed on Day 1 (the same day you complete the screening tests and sign this consent form):

• You will be asked to complete some computer-based questionnaires or paper/pencil questionnaires that will include questions about your feelings, moods, and smoking status. These will take 60-90 minutes to complete.
• You will have your height, weight, and waistline measured.
• Your blood pressure will be measured by a trained research staff member
• You will complete a breath test to help researchers estimate (guess) the amount of cigarette smoke you inhale. The breath test uses a disposable cardboard tube that is attached to a machine, and you will be asked to blow a long, slow, steady breath into it.
• You will be given an accelerometer to wear for 7 days. An accelerometer is a small device that is worn on the waistline of your pants that measures your level of physical activity. After 7 days, you will be asked to "turn off" and mail back the accelerometer using a prepaid envelope provided by the study staff.
• You will give a saliva sample at this visit. To collect the saliva sample, you will place a piece of cotton in your mouth for 3 minutes. The saliva sample is used to check the amount of cotinine in the body. Cotinine is a chemical that is produced in your saliva when your body breaks down nicotine.

Study Groups and Study Procedures:

At the Day 1 study visit, you will be randomly assigned (as in the flip of a coin) into 1 of 2 study groups. There is an equal chance of being assigned to either group.

Participants in both groups will receive health education on Day 1, and again 6 and 12 months later. You can also ask to receive a 6-week supply of nicotine patches, whenever you are ready to try to quit smoking and a home-based exercise kit when you are ready to begin an exercise program.

At the Day 1 health education session, the following will take place:

• You will have a brief counseling session with a study staff member to talk about smoking, diet, and your physical activity level.
• You will be offered referrals to available resources for help with your smoking cessation, diet, and physical activity.
• You will be given a home-based exercise kit, along with self-help materials that are designed to help you learn how to quit smoking and how to improve your diet and physical activity.

At the Months 6 and 12 health education sessions, the Day 1 activities will be repeated, and the following procedures will also take place:

• You will complete a computer-based or paper/pencil questionnaire about your mood, diet, and physical activity. This will take 60-90 minutes to complete.
• Your weight and waistline will be measured.
• You will complete a breath test. The breath test uses a disposable cardboard tube that is attached to a machine, and you will be asked to blow a long, slow, steady breath into it.
• You will give a saliva sample. To collect the saliva sample, you will place a piece of cotton in your mouth for 3 minutes. The saliva sample is used to check the amount of cotinine in the body. Cotinine is a chemical that is produced in your saliva when your body breaks down nicotine.
• You will be given an accelerometer to wear for 7 days. After 7 days, you will mail back the accelerometer using a prepaid envelope provided by the study staff.

You will also have a follow-up study visit at Month 18. During this visit, the same procedures from the Month 12 visit will be performed. However, you will not have a health education session at Month 18.

Wellness Program:

In addition to the health education visits and materials, participants in Group 2 will also take part in the wellness program. For the wellness program, you will receive 18 counseling phone calls over the 18 months you are on study. Each of these phone calls should last about 20-30 minutes.

The telephone counseling sessions will be digitally recorded. Audio recordings will be erased once the data have been published. The recordings will be used to help the researchers make sure that the counselors are following the correct procedures and may be used in the future to help the researchers better understand or improve the counseling treatment. No one but the researchers and their staff will be allowed to view or listen to the recordings, and the identity of the participants will be kept strictly confidential. Your study identification number will be stated by the counselor at the beginning of the taped session. The recordings are stored digitally, encrypted, and password protected.

Questionnaire Data:

Your questionnaire data will be used for research purposes only. Your responses will not be shared with your doctor. If you feel you need a doctor's opinion about anything that is asked about in the questionnaires (such as mental or emotional difficulties or symptoms), please contact either your personal doctor or the study chair.

Length of Study:

You will remain on the study for up to 18 months. Your participation on this part of the study will be over once you complete the study visit at Month 18.

Other Important Information:

• You may be contacted by phone, mail, and/or email at any time while you are taking part in this study to be reminded about the study visits. You will be asked to give the study chair the names and contact information for family members and/or friends that the study staff can contact if they cannot reach you.
• If the accelerometer is lost or stolen, you will not be responsible for the replacement cost, but you should tell the study chair right away.

This is an investigational study. The nicotine patch is FDA approved and commercially available. Up to 500 participants overall will take part in this research study. Up to 400 participants will take part in this portion of the study. All will be enrolled at MD Anderson.

Inclusion Criteria:

1. Latino adults
2. 18 years of age or older
3. Current smoker with a history of smoking an average of at least 1 cigarette per day during the last year
4. Overweight/obese (BMI greater than or equal to 25)
5. Functioning telephone number
6. Valid home address
7. Ability to engage in low to moderate physical activity as determined by the Physical Activity Readiness Questionnaire (PAR-Q)
8. Blood Pressure readings <140/90 mm Hg as defined by the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; Pressure readings >/=140/90 mm Hg will be deemed ineligible to participate and excluded from the study. They will be referred to their family physician or community services. Those ineligible based on their initial blood pressure reading are allowed to participate if they provide a letter from a physician who will continue to monitor the participant during the research study.
9. Can speak, read, and understand Spanish and/or English

Exclusion Criteria:

1. Pregnancy or lactation
2. Participants who were recruited for the pilot and focus groups are not eligible for the randomized trial.
3. Contraindication for nicotine patch use
4. Regular use of tobacco products
5. Current use of tobacco cessation medications
6. Currently enrolled in another smoking cessation study
7. Another household member enrolled in the study
8. Scores below 38 on the Short Assessment of Health Literacy for Spanish Adults (SAHLSA)
9. Active substance abuse or dependence
10. Scores below the 6th grade literacy level on the Rapid Estimate of Adult Literacy in Medicine (REALM)