A Longitudinal Study in 1st Degree Relatives of Parkinson's Disease (PD) Patients

This is a longitudinal study in healthy 1st degree relatives of patients with Parkinson's Disease (PD) carriers of a genetic mutation in genes that are known to increase the risk for PD. The purpose of this study is to explore the association between genetic mutations in the known genes and early preclinical symptoms such as motor, sensory, autonomic, behavioral and cognitive functions.

Inclusion Criteria:

• healthy 1ST degree relatives of PD patients with known genotype that participated in an earlier genetic study at the sourasky medical center.

Exclusion Criteria:

• subjects with cognitive decline by the parameters defined in DSM- IV
• subjects with psychiatric disorder
• subjects unable to sign a consent form