A Longitudinal Study in Parkinson's Disease (PD) Patients

A Longitudinal 5 Years Follow up Study in Parkinson's Disease (PD) Patients Carriers of the LRRK2 Gene G2019S Mutation

This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up

Inclusion Criteria:

• parkinson'd disease patients that already participated in a pasr cross sectional study

Exclusion Criteria:

• subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV
• subjects with psychiatric disorder
• subjects unable to sign a consent form