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| Name | Class |
|---|---|
| Siriraj Hospital | OTHER |
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Ascorbic acid (Vitamin C) could protect renal toxicity from colistin.
Renal toxicity due to colistin therapy is common. Ascorbic acid (vitamin C) has been shown to prevent colistin associated renal toxicity in animals. This study is conducted to determine if acorbic acid can prevent Colistin-Associated Nephrotoxicity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Colistin | Active Comparator | Colistimethate sodium 2.5-5mg/kg iv |
|
| Colistin + Ascorbic acid | Experimental | Colistimethate sodium 2.5-5mg/kg iv and ascorbic acid 2 grams iv every 12 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Colistin | Drug | Colistimethate sodium 2.5-5mg/kg iv per day |
|
| Measure | Description | Time Frame |
|---|---|---|
| number of patients with Renal toxicity associated with colistin | Renal toxicity associated with colistin according to RIFLE criteria | up to 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| number of subjects with cure or improvement | cure improvement worse death | up to 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Visanu Thamlikitkul, MD | Contact | 662-419-7783 | sivth@mahidol.ac.th |
| Name | Affiliation | Role |
|---|---|---|
| Visanu Thamlikitkul, MD | Siriraj Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Siriraj Hospital | Bangkok | Bangkok | 10700 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25801556 | Derived | Sirijatuphat R, Limmahakhun S, Sirivatanauksorn V, Nation RL, Li J, Thamlikitkul V. Preliminary clinical study of the effect of ascorbic acid on colistin-associated nephrotoxicity. Antimicrob Agents Chemother. 2015;59(6):3224-32. doi: 10.1128/AAC.00280-15. Epub 2015 Mar 23. |
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| ID | Term |
|---|---|
| D003091 | Colistin |
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D011113 | Polymyxins |
| D010456 | Peptides, Cyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
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| Colistin + Ascorbic acid | Drug | Colistimethate sodium 2.5-5mg/kg iv per day and ascorbic acid 2 grams iv q 12 hours |
|
|
| D055666 |
| Lipopeptides |
| D008055 | Lipids |
| D023181 | Antimicrobial Cationic Peptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000089882 | Antimicrobial Peptides |
| D052899 | Pore Forming Cytotoxic Proteins |
| D008565 | Membrane Proteins |
| D011506 | Proteins |
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D006880 | Hydroxy Acids |
| D002241 | Carbohydrates |