Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity

Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity

Ascorbic acid (Vitamin C) could protect renal toxicity from colistin.

Renal toxicity due to colistin therapy is common. Ascorbic acid (vitamin C) has been shown to prevent colistin associated renal toxicity in animals. This study is conducted to determine if acorbic acid can prevent Colistin-Associated Nephrotoxicity.

Inclusion Criteria:

• age > 18 years hospitalized patient who needs colistin for therapy of nosocomial infection

Exclusion Criteria:

• pregnant woman
• lactating mother
• allergy to ascorbic acid
• receiving non-steroidal antiinflammatory drugs (NSAID), aminoglycosides, vancomycin, cisplatin, amphotericin-B
• received radiocontrast media within 1 week
• renal stone
• G-6-PD deficiency