Effect of Vitamin D3 on Cardiovascular Risk Factors

Effect of Vitamin D3 on Cardiovascular Risk Factors: a Randomized Trial in Human

The aim of this study is to investigate whether a supplementation of Vitamin D3 can be used to reduce atherosclerotic risk factors.

It is the objective of this study to investigate whether a supplementation with Vitamin D3 can be used to reduce atherosclerotic risk factors such as hypertension, inflammation and hyperlipidemia. The research question is whether Vitamin D3 can lower blood pressure in mildly hypertensive subjects who are naive to antihypertensive medication, whether Vitamin D reduces the level of systemic inflammation and whether Vitamin D3 has an effect on blood lipids.

major outcomes:

- decrease of systolic blood pressure in the treatment group in comparison with the placebo group

Inclusion Criteria:

• human volunteers with mild hypertension

Exclusion Criteria:

• use of antihypertensive medication
• use of vitamin d or calcium supplements
• known renal, inflammatory or malignant diseases
• hypercalcemia or hypercalciuria
• participation in other clinical studies
• use of tanning booths during the study