Genome-wide Association Study

Genome-wide Association Study to Predict Treatment Response for Chemotherapy in Esophageal Squamous Cell Carcinoma

To explore biomarkers predictive of clinical response to Taxane/5-FU/platinum based chemotherapy in esophageal squamous cell carcinoma. To identify negative predictive markers to 5-FU/platinum/Taxane. To elucidate signal transduction pathway attributable to 5-FU/platinum/Taxane resistance. To analyze correlation between the quantity of circulating tumor cells and circulating endothelial cell precursors and treatment response to Taxane/5-FU/platinum based chemotherapy.

Inclusion Criteria:

• Histological confirmed esophageal squamous cell carcinoma
• Patients treated with Taxane or 5-FU or platinum based chemotherapy.
• provision of a signed written informed consent.

Exclusion Criteria:

• patients not signed written informed consent.
• patient unacceptable for study in the judgement of the investigator.