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The scope of the trial is to predict the early complete clinical response to exclusive concomitant radiochemotherapy in esophageal cancer by the study of the pre- and per- therapeutic proteomic profile.
Further informations will be provided by Centre Oscar Lambret.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sampling | Procedure | Before any study treatment, 14 days after radiotherapy, 15 weeks after radiotherapy | ||
| Radiation | Radiation | Week 1 to week 5-6 1.8-2 Gys/fraction, 5 days a week for a total of 5 to 6 weeks | ||
| Chemotherapy (Fluorouracil and Cisplatin) | Drug | At weeks 1, 5, 8 and 11
|
| Measure | Description | Time Frame |
|---|---|---|
| Proteomic analysis by Protein-Chip Technology of Ciphergen and mass spectrometry | 15 weeks after the end of irradiation | |
| Initial complete clinical response | 15 weeks after the end of irradiation |
| Measure | Description | Time Frame |
|---|---|---|
| Prolonged clinical response at one year | One year after the end of irradiation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ADENIS Antoine, MD, PhD | Centre Oscar Lambret | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Paul Papin | Angers | 49933 | France | |||
| Centre Hospitalier Universitaire |
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| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D011827 | Radiation |
| D004358 | Drug Therapy |
| D005472 | Fluorouracil |
| D002945 | Cisplatin |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Brest |
| 29200 |
| France |
| Centre François BACLESSE | Caen | 14046 | France |
| Centre Oscar Lambret | Lille | 59020 | France |
| Centre Eugène Marquis | Rennes | 35042 | France |
| CHU - Hopital Charles Nicolle | Rouen | 76031 | France |
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D055585 | Physical Phenomena |
| D013812 | Therapeutics |
| D014498 | Uracil |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
| D017671 | Platinum Compounds |