Radiographic Progression of Infiltrated Caries Lesions In-vivo

Radiographic Progression of Infiltrated Caries Lesions In-vivo

This study is investigating the efficacy of caries lesion infiltration therapy as compared to the current preventative approach for early caries lesions.

A 3-year longitudinal, prospective, randomized control clinical trial (RCT) is designed incorporating a split-mouth intra-oral design. Young volunteers (14-35 years old) with at least two early lesions in posterior teeth will be enrolled into this clinical trial to evaluate the clinical effectiveness of arresting lesion progression by infiltrating the lesions. The infiltration protocol included application of on-market materials and applicators, and was performed in one session.

Inclusion Criteria:

• 14-35 year old subjects
• decayed-missing-filled permanent teeth (DMFT) ≥ 3
• having at least two early caries lesions in approximal posterior tooth surfaces
• lesion visible on radiograph

Exclusion Criteria:

• Current participation in another clinical study
• Medically compromised subjects
• Hyposalivation
• Pregnancy
• Allergic to methylmethacrylates
• Allergic to latex
• Symptomatic teeth