Estrogen Pretreatment Prior to GnRH Antagonist Protocol

Interest of a Steroid Pre-treatment Prior to IVF Protocol With Ovarian Stimulation by Recombinant FSH and With LH Surge Blockage by Daily GnRH Antagonist

The purpose of this study is to assess whether estrogen pre-treatment can allow retrieval of 2 additional oocytes in GnRH antagonist protocol.

Inclusion Criteria:

• regular normo-ovulatory cycles (28 to 35 days)
• age < 38 years,
• body mass index (BMI) between 18 and 30
• first or second IVF/ICSI attempt

Exclusion Criteria:

• high basal levels of serum FSH or E2,
• less than 5 follicles at the antral follicular count performed on day 3 of a spontaneous cycle,
• history of high (>20 oocytes) or low (< 5 oocytes) ovarian response in a previous IVF attempt