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The purpose of this study is to assess whether estrogen pre-treatment can allow retrieval of 2 additional oocytes in GnRH antagonist protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Estrogen pre-treatment | Active Comparator |
| |
| Control | No Intervention | The control group did not receive any pre-treatment. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 17beta-estradiol | Drug | Pretreatment with 17beta-estradiol (Provames®, Aventis, Paris, France) was administered daily (2 mg twice a day) during the cycle preceding the IVF/ICSI cycle, starting 7 days before the predicted onset of menses and administered up until to the following Thursday after the occurrence of menses. |
| Measure | Description | Time Frame |
|---|---|---|
| number of retrieved oocytes | at the ovarian puncture, 36 hours post HCG administration |
| Measure | Description | Time Frame |
|---|---|---|
| pregnancy rate | at pregnancy test and at 6 Week US examination | |
| delivery rate | 9 months later | |
| number of obtained embryos |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean Noel Hugues, MD, PhD | Hôpital Jean Verdier | Study Director |
| Isabelle cedrin-durnerin, MD | Hôpital Jean Verdier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Medecine de la Reproduction, Hôpital Jean Verdier | Bondy | Île-de-France Region | 93140 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22464760 | Derived | Cedrin-Durnerin I, Guivarc'h-Leveque A, Hugues JN; Groupe d'Etude en Medecine et Endocrinologie de la Reproduction. Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial. Fertil Steril. 2012 Jun;97(6):1359-64.e1. doi: 10.1016/j.fertnstert.2012.02.028. Epub 2012 Mar 28. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D004958 | Estradiol |
| ID | Term |
|---|---|
| D004963 | Estrenes |
| D004962 | Estranes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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|
| 2 days after in vitro fertilization |
| duration of FSH administration | number of days of administration | at the end of ovarian stimulation usually after a mean of 12 days of administration |
| Total FSH dose | daily dose x number of days of administration | at the end of ovarian stimulation usually after a mean of 12 days of administration |
| D011083 |
| Polycyclic Compounds |
| D045166 | Estradiol Congeners |
| D012739 | Gonadal Steroid Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |