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Obtained results were not good. Protocol was proved ineffective.
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To evaluate the effect of oestradiol pre-treatment in a combined ultrashort flare GnRH agonist /GnRH antagonist protocol
The combined ultrashort flare GnRH agonist /GnRH antagonist protocol during COH cycle resulted in a significantly higher clinical pregnancy rate in patients with poor embryo quality, with repeated IVF failures and in poor responders. This is a protocol combining the effect of the microdose flare on endogenous FSH release with the benefit of an immediate LH suppression of the GnRH antagonist.
A major disadvantage of the use of a GnRH antagonist protocol is the limitation for programming cycles, as the drugs administration is started on day 2 of the menstrual cycle and is strictly followed until the hCG criteria are met.
The purpose of the study is to perform oestradiol pre-treatment with the combined ultrashort flare GnRH agonist /GnRH antagonist protocol aiming to
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oestradiol and ultrashort GnRH agonist/antagonist protocol | Experimental | Women will begin pretreatment with 4 mg/day of 17 β-estradiol before the combination of GnRH ultashort agonist and antagonist protocol |
|
| GnRH agonist or antagonist protocol. | Active Comparator | Women will undergo either a conventional short or long GnRH agonist or an antagonist protocol during COH for IVF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oestradiol pre-treatment and combination of GnRH agonist/antagonist protocol | Procedure |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Live birth rate | 2 years | |
| Clinical pregnancy rate | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Number of oocytes retrieved | 2 years | |
| Top embryo quality at day 2 | 2 years | |
| Biochemical pregnancy |
| Measure | Description | Time Frame |
|---|---|---|
| Positive Pregnancy Test | 2 years |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| George Salamalekis, MD, PhD | National and Kapodistrian University of Athens | Principal Investigator |
| Charalampos Siristatidis, Assistant Professor | National and Kapodistrian University of Athens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assisted Reproduction Unit, 3rd Department of Obstetrics and Gynecology. Attikon University Hospital | Athens | Attica | 12642 | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20537631 | Background | Griesinger G, Kolibianakis EM, Venetis C, Diedrich K, Tarlatzis B. Oral contraceptive pretreatment significantly reduces ongoing pregnancy likelihood in gonadotropin-releasing hormone antagonist cycles: an updated meta-analysis. Fertil Steril. 2010 Nov;94(6):2382-4. doi: 10.1016/j.fertnstert.2010.04.025. Epub 2010 May 26. | |
| 22656307 |
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| GnRH agonist or antagonist protocol without oestradiol pre-treatment |
| Procedure |
|
| 2 years |
| Ectopic pregnancy | 2 years |
| Miscarriage rate | 2 years |
| Bosch E. Can we skip weekends in GnRH antagonist cycles without compromising the final outcome? Fertil Steril. 2012 Jun;97(6):1299-300. doi: 10.1016/j.fertnstert.2012.04.024. No abstract available. |
| 18675974 | Result | Orvieto R, Nahum R, Rabinson J, Gemer O, Anteby EY, Meltcer S. Ultrashort flare GnRH agonist combined with flexible multidose GnRH antagonist for patients with repeated IVF failures and poor embryo quality. Fertil Steril. 2009 Apr;91(4 Suppl):1398-400. doi: 10.1016/j.fertnstert.2008.04.064. Epub 2008 Aug 3. |
| 22464760 | Result | Cedrin-Durnerin I, Guivarc'h-Leveque A, Hugues JN; Groupe d'Etude en Medecine et Endocrinologie de la Reproduction. Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial. Fertil Steril. 2012 Jun;97(6):1359-64.e1. doi: 10.1016/j.fertnstert.2012.02.028. Epub 2012 Mar 28. |
| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D007987 | Gonadotropin-Releasing Hormone |
| ID | Term |
|---|---|
| D010906 | Pituitary Hormone-Releasing Hormones |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
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