The purpose of this study is to determine the effect of plug placement on the efficacy, safety and duration of effect of the L-PPDS (latanoprost punctal plug delivery system).

Inclusion Criteria:

• Male or female at least 18 years old
• Diagnosis of bilateral open angle glaucoma or ocular hypertension
• Unmedicated IOP must be ≥22mm Hg

Exclusion Criteria:

• Any significant vision loss in the last year
• No contact lens use for the length of the study
• Abnormal eye lids, eye infection or diseases to the eye
• Recent eye surgery
• Uncontrolled medical conditions