The purpose of this study is to test if latanoprost punctal plugs will reduce eye pressure in subjects with ocular hypertension or open-angle glaucoma.

Inclusion Criteria:

• Diagnosed with bilateral OH or OAG and on topical prostaglandin monotherapy bilaterally as standard of care for treatment of OH or OAG.
• Adequate IOP control on topical prostaglandin monotherapy during the past 1 month.

Exclusion Criteria:

• Functionally significant vision loss, or progressive field loss within the last year.
• Contact lens wear at any time during the treatment period.
• Keratoconjunctivitis sicca requiring chronic topical artificial tears, lubricants, and/or Restasis®.
• Active lid disease (i.e., moderate or severe blepharitis, meibomianitis) that requires medical treatment.
• Subjects with ≥0.9 vertical cup or completely notched optic nerve head rim.
• Currently on chronic ocular topical medications
• Currently on any ophthalmic or systemic steroid therapy.
• Laser surgery for glaucoma within the last 3 months or 6 months for incisional surgeries.
• History of macular edema
• History of chronic/recurrent inflammatory eye disease.
• History of a non-response to topical prostaglandin therapy.
• Subjects who have epiphora.