Fish Oil Supplementation and Vascular Function in Hypertensive Patients With Hypertriglyceridemia

Effects of Fish Oil Supplementation on Vascular Structure and Function in Hypertensive Patients With Hypertriglyceridemia

The objective of this study is to compare the effects of ciprofibrate versus omega-3 fatty acid supplementation on the vascular structure and function in hypertensive patients with hypertriglyceridemia.

Hypertensive patients aged 40-65 years, both genders, presenting serum triglycerides levels higher than 150 mg/dl will be randomized into two groups. The first group will be receiving ciprofibrate 100mg/day and the second group will be receiving fish oil 1800mg/day. All patients will be evaluated with brachial flow-mediated dilation and with EndoPAT to assess endothelial function before and after supplementation. SPHYGMOCOR and pulse wave velocity (PWV) measurements will also be obtained.

Inclusion Criteria:

• Previous diagnosis of hypertension
• Patients with serum triglycerides levels ≥ 150 mg/dl and <500 mg/dl
• Patients on stable antihypertensive medication for at least 4 weeks
• Patients with food consumption maintained for at least 4 weeks

Exclusion Criteria:

• Smoking
• Secondary hypertension
• Hormone replacement therapy
• Diabetes mellitus
• Chronic kidney disease
• Known coronary artery disease
• Previous stroke
• Dyslipidemia severe, with LDL cholesterol> 160 mg/dL or triglycerides ≥ 500 mg/dl
• Use of statins or beta blockers