The objective of this study is to compare the effects of ciprofibrate versus omega-3 fatty acid supplementation on the vascular structure and function in hypertensive patients with hypertriglyceridemia.

Hypertensive patients aged 40-65 years, both genders, presenting serum triglycerides levels higher than 150 mg/dl will be randomized into two groups. The first group will be receiving ciprofibrate 100mg/day and the second group will be receiving fish oil 1800mg/day. All patients will be evaluated with brachial flow-mediated dilation and with EndoPAT to assess endothelial function before and after supplementation. SPHYGMOCOR and pulse wave velocity (PWV) measurements will also be obtained.

Inclusion Criteria:

• Previous diagnosis of hypertension
• Patients with serum triglycerides levels ≥ 150 mg/dl and <500 mg/dl
• Patients on stable antihypertensive medication for at least 4 weeks
• Patients with food consumption maintained for at least 4 weeks

Exclusion Criteria:

• Smoking
• Secondary hypertension
• Hormone replacement therapy
• Diabetes mellitus
• Chronic kidney disease
• Known coronary artery disease
• Previous stroke
• Dyslipidemia severe, with LDL cholesterol> 160 mg/dL or triglycerides ≥ 500 mg/dl
• Use of statins or beta blockers