Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis

Predictors of PPI Response in Eosinophilic Esophagitis

The investigators will determine the prevalence of gastroesophageal reflux disease (GERD) in Eosinophilic Esophagitis (EoE) and importantly determine the predictors of response to Proton Pump Inhibitor (PPI) therapy in EoE. Moreover, the investigators will determine the effect of GERD on the location of esophageal eosinophilia.

Inclusion Criteria:

• 18 years of age < 80 years of age

• 14 eosinophils / hpf on biopsies from esophagus

  • Abnormal validated Mayo dysphagia questionnaire (MDQ-30) (question 2"yes", question 4 > "moderate" and question 7 > "once a week")
  • Clinically performed EGD with > 14 eosinophils/hpf completed within last 3 months

Exclusion Criteria:

• Other cause of dysphagia identified at endoscopy (e.g. stricture, web, infection, ring, achalasia, esophageal neoplasm)
• Dilatation of esophagus at time of index endoscopy
• Treatment with topical steroid within 3 months of index endoscopy
• Treatment with PPI in last 30 days prior to index EGD

Patient population - adults with EoE recruited from Mayo Clinic Rochester, MN patient population