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| Name | Class |
|---|---|
| Pharmaceutical Research Center | UNKNOWN |
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Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group3 | Active Comparator | Normal controls |
|
| Group4 | Placebo Comparator | Normal controls |
|
| Group 1 | Active Comparator | Hypothyroid patients taking levothyroxin. |
|
| Group2 | Placebo Comparator | Hypothyroid patients taking levothyroxin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Carum Cravi | Drug | 40mg/kg of body weight |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Thyroid and thyrotropin values from baseline at 2 and 6 weeks | TSH, Free T4, Free T3, T4RIA and T3RIA | 0-2-6 Weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change of hypothyroidism index from baseline at 2 and 6 weeks | Hypothyroidism Index | 0,2 and 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Seyed Rasoul Zakavi, MD,IBNM | Contact | +98-511-8022729 | zakavir@mums.ac.ir | |
| Zohre Mousavi, MD, IBE | Contact | +98-8599359 |
| Name | Affiliation | Role |
|---|---|---|
| Seyed Rasoul Zakavi, MD. IBNM | Nuclear Medicine Research Center | Principal Investigator |
| Mohammad Ramezani, Ph.D., Pharm.D | Pharmaceutical Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nuclear Medicine Department, Ghaem Hospital | Recruiting | Mashhad | Iran |
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| Placebo |
| Drug |
Placebo |
|