Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism

Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism

Hypothyroidism is risk factor in atherosclerotic cardiovascular diseases, but there is a controversy in effect of subclinical hypothyroidism on cardiovascular diseases. We aim to estimate the relation between subclinical hypothyroidism and endothelial dysfunction and the effects of levothyroxine therapy on it. Patients with confirmed subclinical hypothyroidism by lab results will be randomized to two groups of treatment with one daily dose of 100 mg Levothyroxine or placebo. The flow-mediated dilation and intima media thickness are evaluated before and after the study.

Inclusion Criteria:

• age 18 to 65
• confirmed subclinical hypothyroidism

Exclusion Criteria:

• receiving of other treatments for hypothyroidism
• patients with other major medical disorders
• smoking
• hyperlipidemia
• obesity