The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy

The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy

This is a single center,prospective,no-controlled clinical trial

1. The complete remission of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients
2. The safety of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients

Inclusion Criteria:

• Female or male patients aged between 18 to 65 years
• Renal biopsy was used to diagnose IgA nephropathy
• Patients with 24h proteinuria 3.5g and serum albumin concentration lower than 30g/L

Exclusion Criteria:

• Patients with serum creatinine ≥ 3 mg/dl or eGFR < 30ml/min per 1.73 m2
• urine RBC > 1 million/ml
• Patients who have received treatment of enough steroids for more than 12 weeks
• patients with secondary IgA
• Patients who have impaired liver function,with ALT/GPT or AST/GOT twice more than the normal upper limit or who have active hepatitis
• Patients with 2 type diabetes or obesity, whose BMI is more than 28kg/m2