Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy

A Prospective Randomized, Controlled, Open-labeled Trial of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy

Treatment of prednisone plus cyclophosphamide may be superior to treatment of prednisone alone in patients with advanced-stage IgA nephropathy.

Inclusion Criteria:

• biopsy-proven primary IgA nephropathy;
• 18-70 years old;
• elevated serum Creatinine and less than 3.0mg/dl;
• with a written consent from participants to receive prednisone and/or cyclophosphamide

Exclusion Criteria:

• diabetes;
• contraindications for the treatment of prednisone and/or cyclophosphamide;
• any treatment with steroids or immunosuppressive drugs prior to this study;
• acute deterioration of renal function(including those of glomerular origin)