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| Name | Class |
|---|---|
| Umeå University | OTHER |
| Quadram Institute Bioscience | OTHER |
| VTT Technical Research Centre of Finland | OTHER |
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This study aims to investigate the direct effect of high amounts of dietary fibre and high amounts of red meat in daily diet on intestinal microbiota, anthropometry and obesity markers in healthy adults.
Human gut microbiota composition and its bacterial pathways are involved in many metabolic processes, including digestion of actually indigestible food components and fat storage. Due to that it may contributes to the developement of obesity being one of the most important risk factors for many chronic diseases. Gut microbiota is under the influence of nutrition, consumption of pro- and prebiotics can promote the growth of certain bacterial strains. In a cross over dietary intervention this work will investigate the effect of defined diets on the intestinal microbiota in 20 healthy adults. The diets contain either high amounts (more than 40g/d) of dietary fibre and low red meat (less than 30g/d) or low amounts (less than 20g/d) of dietary fibre and high amounts of red meat (200g/d). Intervention periods last 3 weeks each interrupted by a 3 weeks wash out period. Examination of participants will happen at the beginning and at the end of both interventions and will contain anthropometry, blood sample, faecal sample, urine sample and saliva sample.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low meat high fibre (lmhf) | Active Comparator | consumption of less than 30g red meat per day and at least 40g dietary fibre per day |
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| high meat low fibre (hmlf) | Active Comparator | consumption of 200g red meat and not more than 20g dietary fibre per day |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low meat high fibre | Dietary Supplement | less than 30g red meat and at least 40g dietary fibre per day |
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| Measure | Description | Time Frame |
|---|---|---|
| change in gut microbiota composition | baseline, week 3, 6 and 9 |
| Measure | Description | Time Frame |
|---|---|---|
| change in anthropometry | Body height, body weight, circumferences of waist, hip, upper arm and leg, lower leg and the thickness of body folds at waist, back, upper arm and leg, lower leg and thorax depth and width | baseline, week 3, 6 and 9 |
| change in blood markers |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jana Foerster, PhD student | German Institute of Human Nutrition Potsdam-Rehbruecke | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25299601 | Derived | Foerster J, Maskarinec G, Reichardt N, Tett A, Narbad A, Blaut M, Boeing H. The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial. PLoS One. 2014 Oct 9;9(10):e109606. doi: 10.1371/journal.pone.0109606. eCollection 2014. |
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| high meat low fibre | Dietary Supplement | at least 200g red meat (pork, beef or other mammals) and not more than 20g dietary fibre per day |
|
clinical blood count, including Hba1c, gamma-GT, cholesterol, HDL, LDL, Triglycerides, s-creatinin, CRP |
| baseline, week 3, 6 and 9 |
| change in salivary microbial composition | baseline, week 3, 6 and 9 |