Aprepitant for Postoperative Nausea and Vomiting in Laparoscopic Hysterectomy

• Gynecological surgery is associated with a high incidence of postoperative nausea and vomiting.
• NK1 receptor antagonists such as aprepitant appear to be highly effective for treating acute and delayed emesis, and yet understanding of the efficacy of different doses of aprepitant is limited.
• We performed a prospective, randomized, double-blinded placebo-controlled study of 123 female adults scheduled for laparoscopic hysterectomy who received 80 mg aprepitant, 125 mg aprepitant, or a placebo.

123 female patients (ages 21-60) undergoing laparoscopic hysterectomy

1. 80mg aprepitant
2. 125mg aprepitant
3. placebo

Incidences of nausea, vomiting/retching, and use of rescue antiemetics were recorded at 0, 1, 2, 24, and 48 h after surgery.

Inclusion Criteria:

• female laparoscopic hysterectomy isoflurane anesthesia postoperative opioid use

Exclusion Criteria:

• liver disease neurologic disease active pulmonary disease cardiac arrhythmia allergies to any perioperative medications