Aprepitant for Post-operative Nausea

Aprepitant vs. Placebo for the Prevention of Postoperative Nausea and Vomiting: a Randomized, Double-blind Study in Patients Undergoing Laparoscopic Cholecystectomy

Anesthesia, especially for laparoscopic surgery, can cause post-operative nausea and vomiting. Most patients are given two drugs, decadron and ondansetron, to try to minimize this. This study is to determine if a new drug, aprepitant, would add any benefit in terms of post-op nausea prevention. All laparoscopic cholecystectomy study patients will receive decadron and ondansetron. Half the patients will receive aprepitant in addition. The other half will receive placebo. The study will be randomized and double-blind.

Inclusion Criteria:

• Laparoscopic cholecystectomy patients.
• Must be able to swallow a pill.

Exclusion Criteria:

• Liver failure,
• Age less than 18.
• Pregnancy, breast-feeding.
• Pre-op vomiting.
• Allergy to aprepitant.
• Need for post-op gastric drainage.
• Use of drugs that interact with aprepitant.