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The study hypothesis is that F-18-FDG PET/CT and microcalorimetry might have a diagnostic value in the detection of permanent central venous catheters (PCVC) infection when conventional means of PCVC infection detection are non-conclusive.
Permanent central venous catheters are frequently infected and therefore need surgical removal. When a clear diagnostic for infection cannot be defined, catheter removal might be at risk for the patient, for the therapeutic follow-up and in terms of costs. PET/CT and microcalorimetry might help giving conclusive diagnostic of catheter infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Confirmed CVCP infection before removal | Patients with permanent central venous catheter infection confirmed by conventional method | ||
| Presumed CPVP infection before removal | Patients with probable permanent central venous catheter infection (standard methods for infection detection not conclusive) | ||
| Uninfected CVCP before removal | Patients with planned permanent central venous catheter removal (no infection) |
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| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of F-18-FDG PET/CT imaging in the detection of CVCP infection | To determine the clinical use of PET/CT in the detection of catheter infection by comparing PET/CT imaging results to standard means of catheter infection detection (i.e. clinical signs and hemoculture [positive or negative]) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of microcalorimetry in the detection of CVCP infection | To determine the clinical use of microcalorimetry in the detection of catheter infection by comparing microcalorimetry results to standard means of catheter infection detection (i.e. clinical signs and hemoculture [positive or negative]) | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with pathology requiring permanent central venous catheter will be selected mainly from nephrology and oncology departments . They might also be selected from other deparments.
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| Name | Affiliation | Role |
|---|---|---|
| John O Prior, PhD MD | Centre Hospitalier Universitaire Vaudois and University of Lausanne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire Vaudois, Nuclear Medicine | Lausanne | Canton of Vaud | 1011 | Switzerland |
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| ID | Term |
|---|---|
| D007239 | Infections |
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