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The proposed study is a multicentric prospective observational cohort study of patients with suspected NVE. The study population includes those with Possible IE according to the modified Duke criteria and investigated at one of the 6 participating sites which include 2 cardiac centers, the MHI and the IUCPQ, as well as 4 tertiary care centers, the Jewish General Hospital , the McGill University Health Centre and the CHUS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with suspected native valve endocarditis |
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with Possible IE that will be appropriately reclassified | Proportion of patients with Possible IE that will be appropriately reclassified as Definite IE by the addition of FDG-PET to the Duke criteria. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity, specificity, and accuracy of FDG-PET for the detection of NVE | 3 months | |
| Sensitivity, specificity, and accuracy of the Duke criteria with FDG-PET for detection of NVESensitivity, specificity, and accuracy of the Duke criteria with FDG-PET for detection of NVE |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between the diagnostic accuracy and available demographic, technical, and clinical factors | Correlation between the diagnostic accuracy (false-negative/false-positive studies versus truenegative/true-positive) and the available demographic and clinical factors (age, sex, duration of antibiotherapy, blood glucose, CRP, history of renal failure, history of malignancy, history of diabetes, chronic liver disease, time since onset of symptoms, and quality of myocardial suppression) as well as camera system (analog vs digital) |
Inclusion Criteria:
Exclusion Criteria:
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The study population includes those with Possible IE according to the modified Duke criteria and investigated at one of the 5 participating sites
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier de l'Universite de Montreal | Not yet recruiting | Montreal | Quebec | H2X 3E4 | Canada |
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| ID | Term |
|---|---|
| D004696 | Endocarditis |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 3 months |
| Sensitivity, specificity, and accuracy of the Duke criteria with FDG-PET but excluding TEE for the detection of NVE | 3 months |
| Differences in maximal standardized uptake value (SUVmax) between infected and non-infected valves | 3 months |
| Differences target-to-background ratio (TBR) between infected and non-infected valves | 3 months |
| Proportion of patients in whom a TEE was not necessary to diagnose NVE through the addition of FDG-PET | 3 months |
| Proportion of patients with final diagnosis of IE with septic emboli detected on whole body FDGPET | 3 months |
| Differences in the rate of sub-optimal suppression protocol between males and females | 3 months |
| Proportion of patients with incidental cancer identified on FDG-PET | 3 months |
| 3 months |
| Difference in the area under the curve (c-statistic) of the Duke criteria with TEE but excluding FDG-PET, with TEE and FDG-PET, and with FDG-PET but excluding TEE | 3 months |
| Differences in sensitivity, specificity, and accuracy of FDG-PET with and without respiratory and ECG-gated acquisitions | 3 months |
| Montreal Heart Institute | Recruiting | Montreal | Quebec | H3l 3c1 | Canada |
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| Jewish General Hospital | Recruiting | Montreal | Quebec | H3T 1E2 | Canada |
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| McGill University Health Center | Not yet recruiting | Montreal | Quebec | H4A 3J1 | Canada |
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| University Institute of Cardiology and Respirology of Quebec | Not yet recruiting | Québec | Quebec | G1V 4G5 | Canada |
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| Centre Hospitalier de l'Universite de Sherbrooke | Not yet recruiting | Sherbrooke | Quebec | J1H5H3 | Canada |
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