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| Name | Class |
|---|---|
| Kenya Medical Research Institute | OTHER |
| University of California, San Francisco | OTHER |
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Early accurate diagnosis is one of the first crucial steps in care for infants born to HIV-infected mothers. Early initiation of antiretroviral therapy (ART) relies upon early diagnosis and results in significant reductions in infant morbidity and mortality. There is little information on evidence-based interventions that specifically target improved attendance of postpartum clinic visits and subsequent infant HIV testing in the context of prevention of mother-to-child transmission of HIV (PMTCT) programs. The investigators propose a randomized controlled trial to examine the effect of text messages sent to women enrolled in PMTCT programs on adherence to postpartum clinic visits and uptake of early infant diagnosis by DNA polymerase chain reaction (PCR). This study seeks to test the hypotheses that (a) text messages sent to women enrolled in PMTCT will improve their attendance at the postnatal clinic within the first 6-8 weeks after childbirth; and (b) text messages sent to women enrolled in PMTCT programs will increase uptake of DNA PCR HIV testing at 6-8 weeks among infants exposed to HIV. This study will evaluate a novel strategy to improve adherence to postnatal clinic visits and increase the uptake of infant HIV testing. If proven superior to standard care, the proposed intervention can be easily scaled-up and integrated into existing healthcare systems in resource-limited settings. Findings from this study will provide randomized trial evidence to inform HIV prevention program planners and implementers. This study will also provide further information on the feasibility of using mobile phone-based technology for public health interventions in resource-limited settings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Text message (SMS) | Experimental | Text messages sent to women before and after delivery |
|
| Usual care (current standard of care) | No Intervention | Current standard of care for women enrolled in PMTCT programs |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Text message | Other | Text messages sent to women before and after delivery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of women who attend postnatal clinic within 6-8 weeks postpartum | 6-8 weeks after delivery | |
| Proportion of infants tested for HIV by DNA PCR | 6-8 weeks after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Infant adherence to antiretroviral prophylaxis | Up to 6 weeks after delivery | |
| Time to post-natal clinic return | Up to 8 weeks after delivery | |
| Maternal adherence to antiretroviral prophylaxis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thomas A Odeny, MBChB, MPH | University of Washington/Kenya Medical Research Institute | Principal Investigator |
| R Scott McClelland, MD, MPH | University of Washington | Study Chair |
| Craig R Cohen, MD, MPH | University of California, San Francisco | Study Chair |
| Carol Camlin, PhD | University of California, San Francisco | Study Chair |
| Elizabeth A Bukusi, MBChB, MMed, MPH, PhD | Kenya Medical Research Institute | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kenya Medical Research Institute, Family AIDS Care and Education Services | Kisumu | Nyanza | Kenya |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25313586 | Result | Odeny TA, Bukusi EA, Cohen CR, Yuhas K, Camlin CS, McClelland RS. Texting improves testing: a randomized trial of two-way SMS to increase postpartum prevention of mother-to-child transmission retention and infant HIV testing. AIDS. 2014 Sep 24;28(15):2307-12. doi: 10.1097/QAD.0000000000000409. | |
| 25181408 | Result |
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| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000163 | Acquired Immunodeficiency Syndrome |
| D010349 | Patient Compliance |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
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| ID | Term |
|---|---|
| D013097 | Spermine Synthase |
| ID | Term |
|---|---|
| D019883 | Alkyl and Aryl Transferases |
| D014166 | Transferases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
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| Up to 8 weeks after delivery |
| Odeny TA, Newman M, Bukusi EA, McClelland RS, Cohen CR, Camlin CS. Developing content for a mHealth intervention to promote postpartum retention in prevention of mother-to-child HIV transmission programs and early infant diagnosis of HIV: a qualitative study. PLoS One. 2014 Sep 2;9(9):e106383. doi: 10.1371/journal.pone.0106383. eCollection 2014. |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D012897 | Slow Virus Diseases |
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |