Pharmacogenetic Study of Different Hormone Therapies in Recent Menopause Women

Polymorphisms in Genes Encoding the Estrogen Metabolism Enzymes and Effects of Hormone Therapy for Oral Low Dose or Not Oral on Variables Related Endothelial Function, Inflammation and Metabolic Profile in Patients in Recent Menopause Study Pharmacogenetic

This is cross-over, randomized clinical trial, with objective to evaluate the effects of low-dose oral hormone therapy and non-oral hormone therapy on endothelial function markers (fibrinogen, von Willebrand factor, c-reactive protein), natriuretic peptide and on anthropometric, metabolic and hormonal variables in early and healthy postmenopausal women and analyzing polymorphisms in the estrogen receptor gene and FTO polymorphisms

Patients will be randomized to receive oral hormone treatment or non-oral hormone treatment

The investigators hypothesis is that a different genotypes in the receptor estrogen gene and FTO may have an influences on treatment response in metabolic markers and cardiovascular risk

Inclusion criteria:

• last menstrual period between 6 months and 3 years before the beginning of the study plus FSH levels higher than 35 IU/L;
• age between 42 and 58 years;
• no use of any medication known to interfere with hormonal, glucose, or lipoprotein levels in the past 3 months;
• no use of steroidal or no steroidal anti-inflammatory drugs in the last 15 days.

Exclusion criteria:

• patients with diabetes,
• previous hysterectomy,
• endometrial thickness >0.5cm,
• history of cancer,
• thromboembolism, or
• established cardiovascular disease