This study will develop a model for the assessment of successful activation/engagement of estrogen receptor beta using salivary biomarkers.

Inclusion Criteria:

• Subject is healthy, postmenopausal woman at least 40 years of age with onset of menopause within 10 years of screening
• Subject has a normal mammogram at screening
• Subject has had a normal Pap-smear within 3 years of screening. Subjects who have not had a Pap-smear in the last 3 years will have the option to have the test at screening
• Subject agrees to avoid medications that cause dry mouth or otherwise affect saliva flow
• Subject is willing to avoid strenuous exercise during the study
• Subject is willing to avoid use of mouthwash or salt water rinses during the study
• Subject is willing to avoid use of teeth whitening products
• Subject is willing to avoid eating and/or drinking grapefruit products
• Subject is willing to limit alcohol consumption to 2 drinks a day
• Subject is willing to limit caffeine consumption to 3 cups of coffee (or equivalent) per day
• Subject is a non-smoker

Exclusion Criteria:

• Subject has a history of multiple and/or severe allergies to drugs or food
• Subject has a cold or viral infection within 2 weeks of Visit 2
• Subject is taking antibiotics within 2 weeks of Visit 2
• Subject needs dental work or procedures during the study
• Subject has used any estrogen or progesterone preparation or product containing phytoestrogens within 3 months of screening
• Subject is unable to discontinue anti-coagulants

AEs were collected from the time the subject signed the consent form until 14 days following the last dose of study medication.

AEs were assessed by clinical evaluation including vital signs, physical examination, medical history, clinical laboratory safety assessment (chemistry, hematology, urinalysis) and ECG at time points specified in the study. Subjects were queried at each visit for any clinical adverse experiences that may have occurred since the previous visit.