Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation

The Influence of Two Different Premedication Protocols for Endotracheal Intubation in Neonates on Cerebral Oxygenation

The purpose of this study is to examine the influence of premedication drugs Atropin, Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac output in term and preterm newborn infants. Two different protocols of premedication are compared.

Influence of the following procedures will be examined:

• Application of Atropin
• Application of Fentanyl
• Application of Mivacurium
• possible desaturation and / or bradycardia during intubation attempts
• restoration of arterial oxygen saturation and / or heart rate after succesful intubation

We aim to examine the change of the following parameters by the use of electrical cardiometry:

• stroke volume
• cardiac output

We compare two different premedication protocols and we evaluate the impact of these protocol on the time needed for intubation and on intubation difficulties .

Inclusion Criteria:

• newborn infant below 44 weeks postmenstrual age
• indication for elective or semi-elective endotracheal Intubation
• parental informed consent

Exclusion Criteria:

• emergency intubation