Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages

Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages: a Randomized Clinical Trial

The purpose of this study is to determine whether sildenafil citrate is effective in improving uterine artery blood flow and oxidative stress in patients with unexplained recurrent miscarriages

Inclusion Criteria:

• Age 18-35 years
• Three or more recurrent miscarriages before the 24th week of gestation with no apparent cause for their previous losses
• Three or more months have elapsed since the last abortion
• Postmenstrual period
• No other therapy allowed during our treatment course

Exclusion Criteria:

• Concomitant use of organic nitrites, or nitrates
• Severe hepatic, renal, or cardiovascular impairment
• History of stroke or myocardial infarction
• Patients with retinitis pigmentosa.