Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development

Effect of Sildenafil Citrate on the Outcome of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development

The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF

sildenafil citrate may increase endometrial thickness in women with recurrent IVF failure attributed to poor endometrial development

Inclusion Criteria:

• (1) cases of infertility, older than 20 years of age and not older than 40 years.
• (2) Body mass index (BMI):20-29.
• (3) women have experienced two or more implantation failure attributed to inadequate endometrial development.

Exclusion Criteria:

• (1) Uterine abnormalities (e.g. septate, bicornuate and fibroid uterus, Asherman Syndrome).

• (2) Any contraindication to sildenafil citrate or any of the components of its formulation including:

  • Concurrent use of organic nitrites and nitrates.
  • Severe hepatic impairment.
  • Severe renal impairment.
  • Hypotension.
  • Recent stroke or heart attack.