Study to Evaluate if Neoadjuvant Radiotherapy Improves Recurrence Free Survival in Pancreatic Head Cancer

Neoadjuvant Radiotherapy in Patients With Primary Resectable Adenocarcinoma of the Pancreatic Head Plus Adjuvant Chemotherapy: a Randomized Controlled Phase III Trial

Net-Pac investigates if radiation prior to surgical resection improves survival in patients with pancreatic head cancer without metastases.

The trial is designed to show that neoadjuvant radiotherapy followed by surgery improves local recurrence free survival compared to surgery alone in patients with resectable adenocarcinoma of the pancreatic head.

Inclusion Criteria:

• Histologically confirmed adenocarcinoma of the pancreatic head
• Age ≥ 18 years
• Signed informed consent
• ECOG performance status of 0-2

Exclusion Criteria:

• Curative resection is not feasible or presence of metastatic disease
• Patients not eligible for surgery (ASA ≥ 4)
• Participation in an other clinical trial
• Unable or unwilling to sign the informed consent