The purpose of this study is to test the safety of focused radiation (Stereotactic Body Radiation Therapy, SBRT) on patients with pancreatic cancer that will be removed surgically.

Inclusion Criteria:

• Age >18 years.
• Histologically confirmed pancreatic adenocarcinoma of the head and/or body; at least the majority of the histopathologic specimen must be identified as adenocarcinoma.
• Pancreatic tumors must be considered resectable at time of treatment planning. Definition of resectable: no metastases, less than 180 degree involvement of superior mesenteric vein or portal vein, no involvement of hepatic artery, superior mesenteric artery or celiac artery
• No active infection requiring hospitalization
• Adequate labs
• Life expectancy > 3 months.
• Patient is to have received chemotherapy prior to enrollment. This will typically consist of 3-4 cycles of chemotherapy. Patients will have a 2 week break between last chemotherapy administration and start of SBRT.

Exclusion Criteria:

• Presence of metastatic disease.
• Infections requiring systemic antibiotic treatment.

AEs will be collected up to 12 months after the start of treatment.

The definition does not differ from the definitions used from the clinicaltrial.gov definitions.