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In the present study the investigators are trying to evaluate the effect of Murraya koenigii leaves, Punica granatum and Curcuma which is administered to the patients in a combined form as tea. This study will help to evaluate the effect of these preparations scientifically in improving the IBS symptoms.
see above
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Tea decoction made of Graminis Flores abd Maidis stigmata. |
|
| Ayurvedic herbs | Experimental | Tea decoction made of Murraya koenigii leaves, Punica granatum and Curcuma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ayurvedic Herbs | Drug | A tea made of Murraya koenigii leaves, Punica granatum and Curcuma as powder. Decoction of 12ml powder in 100ml hot water is taken twice daily at least 30 minutes before a meal. |
| Measure | Description | Time Frame |
|---|---|---|
| irritable bowel syndrome- symptom severity score | IBS-SSS(Francis, 1997) | T2 (Day 28) |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of abdominal discomfort/Pain | Diary, daily rating of pain | last week of treatment (days 21-28) |
| Intensity of Abdominal Pain/Discomfort | Diary, daily rating of pain on a 100mm Visual Analog Scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jost Langhorst, Prof., MD | University Duisburg-Essen, Chair of Integrative Gastroenterology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinik für Naturheilkunde und Integrative Medizin | Essen | North Rhine-Westphalia | 45276 | Germany |
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| ID | Term |
|---|---|
| D043183 | Irritable Bowel Syndrome |
| ID | Term |
|---|---|
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| Placebo tea | Drug | Graminis Flores and Maidis stigmata as a powder. Decoction made of 12ml in 100ml hot water. To drink twice daily at least 30 Minutes before a meal. |
|
| Last week of treatment (days 21-28) |
| Stool and diarrhea Frequency | Diary, daily counts | last week of treatment (days 21-28) |
| Quality of life | measured with the EQ-5D | T2 (Day 28) |
| IBS Specific Quality of life | measured with the IBS-QOL (Patrick, 1998) | T2 (Day 28) |
| Depression and Anxiety | HADS questionnaire (Hermann, 1995) | T2 (day 28) |
| Adequate Relief Score | Adequate Relief Score (Mangel, 1998) | at day 7, 14, 21 and 28 |
| Global improvement | Question on global improvement: How have your symptomes changed compared to the last week: from much worse to much better on a 7-point scale | at days 7, 14, 21 and 28 |
| adverse events | all adverse events | up to week 15 |
| D004066 | Digestive System Diseases |