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Surgery for cancer of the esophagus is associated with a high risk of postoperative complications. It has been shown that the risk of postoperative complications can be decreased by optimising the amount and type of infusion fluids given during surgery, steered by measurement of cardiac stroke volume, mostly done with a device called esophageal Doppler. This device can however not be used during this type of surgery. This study wants to test the hypothesis that postoperative complications in patients operated for esophageal cancer can be partially prevented by using a goal directed strategy for the administration of fluids and drugs influencing the heart and vessels, based on measurement of stroke volume by pulse wave analysis (FloTrac).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| standard treatment | No Intervention | Fluid and inotropic drugs are given based on conventional parameters such as blood pressure and heart rate as judged by the individual anesthesiologists judgement. | |
| goal-directed fluid treatment | Active Comparator | Stroke Volume and Cardiac Index are measured with the Flotrac/Vigileo system and circulation is optimised |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fluid optimisation | Other | Stroke Volume and Cardiac Index are measured with the Flotrac/Vigileo system and circulation is optimised
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of complications 5 and 30 days postoperatively | 5 and 30 days postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| length of stay ICU and total hospital | 30 days | |
| return of bowel function | 30 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lena Nilsson, MD PhD | University Hospital, Linkoeping | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Linkoeping | Linköping | 58246 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30431499 | Background | Bahlmann H, Halldestam I, Nilsson L. Goal-directed therapy during transthoracic oesophageal resection does not improve outcome: Randomised controlled trial. Eur J Anaesthesiol. 2019 Feb;36(2):153-161. doi: 10.1097/EJA.0000000000000908. |
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| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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|
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |