Study of Tissue Samples From Patients With Non-Small Cell Lung Cancer

Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.

OBJECTIVES:

• To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens.
• To identify and characterize structural variations in the genomes of NSCLC specimens.
• To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation.

OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.

• Patient must have been registered to CALGB 140202.
• Tumor histology should be either primary adenocarcinoma or squamous cell carcinoma of the lung.
• Patients are eligible for this study if their samples from CALGB 140202 are available.
• All living patients must sign the CALGB 151107 consent form to be eligible for this trial.