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Indirect hyperbilirubinemia is frequently observed in premature infants.Probiotics are favorable microorganisms that regulate the flora of the gastrointestinal system. In this study we aimed to compare the effect of S. boulardii on severity of hyperbilirubinemia and duration of phototherapy on very low birth weight infants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Saccharomyces boulardii | Experimental | study group |
|
| placebo | Placebo Comparator | serum physiologic |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Reflor | Dietary Supplement | 5 million unit/day, first 15 day of life |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of S. boulardii on severity of hyperbilirubinemia and phototherapy duration | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| long term effect of S.boulardii on neurodevelopmental outcome | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gamze Demirel, MD | Contact | +905324540156 | kgamze@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gamze Demirel, MD | Zekai Tahir Burak Women's Health Research and Education Hospital | Principal Investigator |
| Ugur Dilmen, Prof | Zekai Tahir Burak Maternit Teaching Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zekai Tahir Burak Maternity Teaching Hospital, Division of Neonatology | Recruiting | Ankara | 06230 | Turkey (Türkiye) |
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| serum physiologic |
| Other |
1 cc added to one feeding in a day |
|