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Probiotics are favorable microorganisms that regulate the flora of the gastrointestinal system and stimulate the immune system. Saccharomyces boulardii was shown to reduce candida colonization. The objective of this study is to evaluate the efficacy of prophylactic S boulardii in reducing the candida colonization and infection in very low birth weight infants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| S. boulardii | Experimental | The patients in this group will be given 5 million unit/day S. boulardii until discharge. |
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| nystatin | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Reflor | Dietary Supplement | 5 million unit/day, orally, beginning on the second day of life, until discharge from hospital |
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| Measure | Description | Time Frame |
|---|---|---|
| Comparison of prophylactic S. boulardii and nystatin on candida colonization and infection in very low birth weight infants | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of S. boulardii on sepsis | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zekai Tahir Burak Maternity Teaching Hospital, Division of Neonatology | Recruiting | Ankara | 06230 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17317426 | Background | Chapman RL. Prevention and treatment of Candida infections in neonates. Semin Perinatol. 2007 Feb;31(1):39-46. doi: 10.1053/j.semperi.2007.01.006. | |
| 20706577 | Background | Murzyn A, Krasowska A, Stefanowicz P, Dziadkowiec D, Lukaszewicz M. Capric acid secreted by S. boulardii inhibits C. albicans filamentous growth, adhesion and biofilm formation. PLoS One. 2010 Aug 10;5(8):e12050. doi: 10.1371/journal.pone.0012050. |
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| mikostatin | Drug | 50000 unit/3 times a day, both for orally and by orogastric route |
|