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| ID | Type | Description | Link |
|---|---|---|---|
| FMMU-XHDD 003 | Registry Identifier | Fourth Military Medical University |
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The purpose of this study is to determine whether transjugular intrahepatic portosystemic shunt (TIPS) with 10-mm covered stent is associated with lower shunt dysfunction in comparing TIPS with 8-mm covered stent in cirrhotic patients with at least one episode of variceal bleeding.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 10-mm covered stent group | Active Comparator | Patients treated with 10-mm covered stent. |
|
| 8-mm covered stent group | Active Comparator | Patients treated with 8-mm covered stent. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 8-mm covered stent group | Device | Creating a shunt between hepatic vein and portal vein with a 8-mm covered stent by TIPS procedure. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of shunt dysfunction. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of variceal rebleeding | 2 years | |
| Incidence of hepatic encephalopathy | 2 years | |
| Survival |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Guohong Han, PhD & MD | Xijing Hospital of Digestive Diseases, Fourth Military Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xijing Hospital of Digestive Diseases, Fourth Military Medical University | Xi'an | Shaanxi | 710032 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20537753 | Background | Riggio O, Ridola L, Angeloni S, Cerini F, Pasquale C, Attili AF, Fanelli F, Merli M, Salvatori FM. Clinical efficacy of transjugular intrahepatic portosystemic shunt created with covered stents with different diameters: results of a randomized controlled trial. J Hepatol. 2010 Aug;53(2):267-72. doi: 10.1016/j.jhep.2010.02.033. Epub 2010 Apr 27. | |
| 28506905 |
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| ID | Term |
|---|---|
| D006975 | Hypertension, Portal |
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| 10-mm covered stent group | Device | Creating a shunt between hepatic vein and portal vein with a 10-mm covered stent by TIPS procedure. |
|
| 2 years |
| Incidence of hepatic myelopathy | 2 years |
| Wang Q, Lv Y, Bai M, Wang Z, Liu H, He C, Niu J, Guo W, Luo B, Yin Z, Bai W, Chen H, Wang E, Xia D, Li X, Yuan J, Han N, Cai H, Li T, Xie H, Xia J, Wang J, Zhang H, Wu K, Fan D, Han G. Eight millimetre covered TIPS does not compromise shunt function but reduces hepatic encephalopathy in preventing variceal rebleeding. J Hepatol. 2017 Sep;67(3):508-516. doi: 10.1016/j.jhep.2017.05.006. Epub 2017 May 12. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |