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| Name | Class |
|---|---|
| Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico | OTHER_GOV |
| Fundação de Amparo à Pesquisa do Estado de São Paulo | OTHER_GOV |
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Obstructive sleep apnea is a multi-component disease. This study will test the hypotheses that hypoxia per se modulates gene expression in animal model of sleep apnea and these results may be translated with alterations that occur in apneic patients. Thus, we aim to integrate basic and clinical research to shed light on novel candidate genes involved in sleep apnea.
Twenty-four male rats were exposed to chronic intermittent hypoxia (5% O2) or normoxia for 6 wks. Following chronic intermittent hypoxia, a group of 8 rats were removed from the chronic intermittent hypoxia protocol and allowed to normoxic conditions over a period of 2 wks. For the clinical protocol, the AHI measured by overnight polysomnography will be use to select individuals with sleep-related breathing disorders, and controls (30-60 years, Body Mass Index (BMI) < 35kg/m2). Moreover, the investigators will evaluate the subjective sleep parameters (sleep disorders questionnaire, the Epworth Sleepiness Scale, sleep diaries). After standard CPAP titration, men with severe obstructive sleep apnea will be assigned for the CPAP protocol for future assessment of the influence of 6 months obstructive sleep apnea treatment. A total of 84 genes are evaluated using the Hypoxia Signaling Pathway PCR Array (SA Biosciences, EUA).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CPAP | Experimental | CPAP - Continuous Positive Airway Pressure, gold standard treatment to Obstructive Sleep Apnea |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continuous Positive Airway Pressure (CPAP) | Procedure | Continuous Positive Airway Pressure (CPAP) is a method of respiratory ventilation used primarily in the treatment of obstructive sleep apnea |
| Measure | Description | Time Frame |
|---|---|---|
| Apnea/Hypopnea Index | Polysomnographic date of sleep stages percentages, sleep efficiency, arousals, apnea-hypopnea index, oxyhemoglobin saturation | 6 months after the basal evaluation |
| Measure | Description | Time Frame |
|---|---|---|
| Gene expression | A total of 84 genes are evaluated using the Hypoxia Signaling Pathway PCR Array (SA Biosciences, EUA), C-reactive protein (CRP), and biochemical parameters | 6 months after the basal evaluation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Juliana C Perry, PhD | Contact | 55-11-8636-9979 | julianaciniperry@gmail.com | |
| Silverio A Garbuio, Master | Contact | 55-11-8611-9251 | silverio.garbuio@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Juliana C Perry, PhD | Federal University of São Paulo | Principal Investigator |
| Lia Rita A Bittencourt, MD, PhD | Associacao Fundo de Incentivo a Psicofarmacologia | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AFIP - Instituto do Sono (Sleep Institute) | Recruiting | São Paulo | São Paulo | 04020-060 | Brazil |
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| Label | URL |
|---|---|
| Hypoxia Signaling Pathway PCR Array (SA Biosciences, EUA) | View source |
| American Academy of Sleep Medicine | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 11, 2012 | |
| Reset | May 7, 2012 | |
| Release | May 28, 2012 | |
| Reset | Jul 20, 2012 | |
| Release | Oct 26, 2012 | |
| Reset | Nov 26, 2012 | |
| Release | Jan 29, 2013 | |
| Reset | Mar 7, 2013 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 11, 2012 | May 7, 2012 | |||
| May 28, 2012 |
| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D045422 | Continuous Positive Airway Pressure |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
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| Jul 20, 2012 |
| Oct 26, 2012 | Nov 26, 2012 |
| Jan 29, 2013 | Mar 7, 2013 |
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012138 |
| Respiratory Therapy |