T-cell-immunity During Standard Radiotherapy in Localised Prostate Cancer

Changes of T-cell-immune-status During Curative Radiotherapy in Prostate Cancer

Immunological effects of radiotherapy have been described before, but not evaluated in a time-dependant manner.

In order to identify a possible time frame for combination therapies, white blood cells are isolated of samples taken at different time points before during and after standard radiotherapy in patients with localised prostate cancer. The overall activity of the T-cell-system as well as tumor-specific T-cell-response are evaluated.

Inclusion Criteria:

• Localised prostate cancer (node negative)
• definitive radiotherapy
• informed consent

Exclusion Criteria:

• medication including steroids or immunosuppressants