Relationship Between Cognitive Function and Pain

Cognitive Function in Healthy Volunteers Exposed to Acute Pain Before and After Administration of Remifentanil

Patients with chronic pain can experience considerable changes in their cognitive function such as forgetfulness, increased absentmindedness, confusion etc. Opioids (e.g. morphine and morphine-like analgesics) are often used in treatment of acute and chronic pain and can lead to worsening of the cognitive function. The interaction between pain, treatment and cognitive function is very complex and is far from understood.

The hypothesis of the present study is that by use of experimental pain in healthy volunteers it will be possible to elucidate the interaction between pain, treatment and cognitive function.

Inclusion Criteria:

• Healthy men aged 18-65 years
• Normal vision and hearing
• No disease associated with cognitive dysfunction

Exclusion Criteria:

• Allergic to remifentanil or patches
• Any use of pain killers or alcohol 48hours before study start
• Current participation in other clinical studies or participation within the last 14days before study start
• Prescribed medication
• Risk of developing
• Previously alcohol- or drug addict
• MMSE score < 26