L'Effet du rémifentanil Sur la sensibilité à la Douleur mesurée Objectivement
L'Effet du rémifentanil Sur la sensibilité à la Douleur mesurée Objectivement
It is a clinical study investigating the relationship between objectively measured pain threshold and the need for escalating doses of remifentanyl opioids. This study is expected to include approximately 40 participants.
The aim of the study is to objectively measure the analgesic effect of an increasing dose of opioids just before anesthesia.
This is a prospective interventional study. Participants will undergo controlled pressure stimulation using an Algometer device to determine their pressure pain threshold (PPT).
Pressure pain threshold will be assessed at baseline (0 ng/mL) and during stepwise increasing target-controlled intravenous remifentanil concentrations of 1, 2, and 3 ng/mL. Measurements will be obtained at each concentration level after achieving steady-state conditions.
Investigators hypothesize that increasing plasma concentrations of remifentanil will be associated with a corresponding increase in pressure pain threshold.
In addition, postoperative analgesic consumption will be recorded following surgery. This will allow the investigators to explore a potential association between intraoperative pressure pain threshold modulation and postoperative pain outcomes or analgesic requirements.
Inclusion Criteria:
Exclusion Criteria:
Refusal to participate;