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The aim of the study is to evaluate the effects of repetitive transcranial magnetic stimulation(rTMS)in the first-episode Schizophrenic patients: the clinical and MRI findings
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| active Risperidone and active rTMS | Active Comparator | active Risperidone and active rTMS for the first-episode schizophrenia patients |
|
| active rTMS and sham Risperidone | Experimental | active rTMS and sham Risperidone for the first-episode schizophrenia |
|
| sham rTMS and active Risperidone | Sham Comparator | sham rTMS and active Risperidone for the first-episode schizophrenia patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| active Risperidone and active rTMS | Other | active Risperidone:------- active rTMS:auditory hallucinations:low-frequency(1Hz)applied over the left temporoparietal cortex(LTPC) negative symptoms:high-frequency（10Hz）applied over the left temporoparietal cortex(LTPC) |
| Measure | Description | Time Frame |
|---|---|---|
| PANSS | 1-6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Total AHRS score | 1-6 weeks | |
| HAMD Score | 1-6 weeks | |
| CGI |
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Inclusion Criteria:
Exclusion Criteria:
Suicide risk
Diagnose of substance abuse/dependance
Severe uncontrolled organic disease that may interfere in the patient´s participation in the study
Contraindication to TMS:
Pregnancy or lactating; note that a negative pregnancy test will be required if the patient is a female in reproductive years
Estimated IQ less than 80
Have a sibling or parent with epilepsy
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yunchun Chen, Ph.D | Contact | +086-13720582601 | Yunchunchen@163.com | |
| Shufang Feng, Ph.D | Contact | +086-13227807801 | fangshuan1984@yahoo.com.cn |
| Name | Affiliation | Role |
|---|---|---|
| Qingrong Tan, Ph.D | Department of Psychiatry, Xi Jing hospital, Xi'an, China | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yun chun Chen | Not yet recruiting | Xi'an | Shaanxi | 710032 | China |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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|
| active rTMS and sham Risperidone | Other | active Risperidone:------- ; active rTMS:auditory hallucinations:low-frequency(1Hz)applied over the left temporoparietal cortex(LTPC); negative symptoms:high-frequency（10Hz）applied over the left temporoparietal; cortex(LTPC) |
|
|
| sham rTMS and active Risperidone | Other | active Risperidone:------- ; active rTMS:auditory hallucinations:low-frequency(1Hz)applied over the left temporoparietal cortex(LTPC); negative symptoms:high-frequency（10Hz）applied over the left temporoparietal; cortex(LTPC) |
|
|
| 1-6 weeks |
| fMRI | 0,6 week |
| Yun chun Chen | Recruiting | Xi'an | Shaanxi | 710032 | China |
|