Renal Denervation in Patients With Resistant Hypertension and Obstructive Sleep Apnea

Effects of Renal Denervation on Blood Pressure and Clinical Course of Obstructive Sleep Apnea in Patients With Resistant Hypertension

The purpose of this study is to investigate the clinical utility of renal denervation for the treatment of resistant hypertension coexisting with obstructive sleep apnea.

Inclusion Criteria:

• >= 18 and =< 70 years of age.
• systolic blood pressure >=140mmHg (office);
• on 3 or more antihypertensive medications (including diuretic)
• mean daytime systolic ABPM >= 135 mmHg
• obstructive sleep apnea (AHI >=15 event/hour, indications for CPAP treatment)

Exclusion Criteria:

• renal artery abnormalities
• eGFR < 60mL/min
• previous TIA, stroke, heart failure
• Type 1 diabetes
• ICD or pacemaker
• others